Nexgard Spectra for Dog XL 66,1-132,3 lbs

Anti-parasitic chewable tablets for dogs. Afoxolaner is an insecticide and acaricide belonging to the isoxazoline family. Afoxolaner acts by interacting with ligand-regulated chloride channels, in particular gamma-aminobutyric acid (GABA) neurotransmitter channels. Of the chloride channel modulators, the isoxazolines bind to a single, distinct target site on insect GABACls, thereby blocking the pre- and postsynaptic transfer of chloride ions across cell membranes. Prolonged afoxolaner-induced hyperexcitation results in uncontrolled central nervous system activity and death of insects and mites. The selective toxicity of afoxolaner between insects, mites and mammals can be inferred from the differential sensitivity of insect and mite GABA receptors to mammalian GABA receptors. It is active against adult fleas as well as several tick species such as Rhipicephalus sanguineus, Dermacentor reticulatus and D. variabilis, Ixodes ricinus and I. scapularis, Amblyomma americanum and Haemaphysalis longicornis. Afoxolaner kills fleas before egg production and therefore prevents the risk of household contamination. It can be used as part of the treatment strategy for the control of Flea Allergic Dermatitis (FAD).